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Tg(AR*100Q)C32Als
Transgene Detail
Summary
Symbol: Tg(AR*100Q)C32Als
Name: transgene insertion C32, Albert La Spada
MGI ID: MGI:5000266
Synonyms: AR100, AR YAC CAG100
Transgene: Tg(AR*100Q)C32Als  Location: unknown  
Alliance: Tg(AR*100Q)C32Als page
Transgene
origin
Germline Transmission:  Earliest citation of germline transmission: J:89772
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(AR*100Q)C32Als expresses 1 gene
 
Mutation detailsThe transgene contains a human YAC in which the CAG repeat contains 100 repeats (100Q). Lines C25 (high expressor) and C32 (low expressor) were generated. (J:89772)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:89772 Sopher BL, et al., Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration. Neuron. 2004 Mar 4;41(5):687-99
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory