Hhex^tm1.1Tmj
Targeted Allele Detail

Summary

• Symbol: Hhex^tm1.1Tmj
• Name: hematopoietically expressed homeobox; targeted mutation 1.1, Thomas M Jessell
• MGI ID: MGI:4999724
• Synonyms: Hexd^act
• Gene: Hhex Location: Chr19:37423289-37429179 bp, + strand Genetic Position: Chr19, 32.28 cM, cytoband D1
• Alliance: Hhex^tm1.1Tmj page

Anterior visceral endoderm defects in Hhex^tm1.1Tmj/Hhex⁺ embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171680
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

Allele Type: Targeted (Inserted expressed sequence) Mutation: Insertion Mutation details: A floxed PGK-neo cassette in reverse orientation and the diphtheria toxin gene were inserted into exon 1 of the gene via homologous recombination. Multiple stop codons in the PGK-neo cassette prevent translation read-through of the diphtheria toxin gene. Cre-mediated recombination removed the neo cassette. (J:171680)

Generation of the Hhex^tm1.1Tmj allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hhex Mutation: 16 strains or lines available

References

• Original: J:171680 Stuckey DW, et al., Correct patterning of the primitive streak requires the anterior visceral endoderm. PLoS One. 2011;6(3):e17620
• All: 1 reference(s)