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Phenotype Image Detail
Image
Caption Anterior visceral endoderm (AVE) defects in Hhextm1.1Tmj/Hhex+ (Hexd activated) embryos. (A) Lefty1/2, (B) Fz8, (C) Cerl, (D) Sfrp5, (E) Dkk1 and (F) Ttr expression in control and mutant embryos at 6.5dpc. Mutant embryos with reduced or lost expression in the AVE = Lefty1/2 n = 13/28; Fz8 n = 4/13; Cerl, n = 7/16; Sfrp5, n = 2/14; Dkk1, n = 0/15; Ttr normal in n = 16/16; Lefty1/2 (L1 and L2) lost from the posterior epiblast in n = 7/28. Scale bar 90 um.
Copyright This image is from Stuckey DW, PLoS One 2011;6(3):e17620, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171680
Associated
Alleles
Symbol Name
Hhextm1.1Tmj hematopoietically expressed homeobox; targeted mutation 1.1, Thomas M Jessell
Associated
Genotypes
Allelic Composition Genetic Background
Hhextm1.1Tmj/Hhex+ involves: 129S1/Sv * FVB/N

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory