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Transgene Detail
Symbol: Tg(PDGFB-LRRK2*R1441C)574Djmo
Name: transgene insertion 574, Darren Moore
MGI ID: MGI:4950673
Synonyms: R1441C-LRRK2
Transgene: Tg(PDGFB-LRRK2*R1441C)574Djmo  Location: unknown  
Strain of Origin:  (C57BL/6J x C3H/HeJ)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(PDGFB-LRRK2*R1441C)574Djmo expresses 1 gene
Mutation detailsThe R1441C-LRRK2 transgene was designed with a minimal cytomegalovirus (CMV) enhancer and human platelet derived growth factor, B polypeptide (PDGFB) promoter/enhancer elements driving expression of full length human leucine-rich repeat kinase 2 (LRRK2) CDNA. LRRK2 cDNA was modified by targeted mutation of the LRRK2 locus to harbor the LRRK2*R1441C mutation associated with autosomal dominant, late-onset Parkinson's disease. Line 574 was generated. (J:171645)
Schematic of the Tg(PDGFB-LRRK2*G2019S)340Djmo or Tg(PDGFB-LRRK2*R1441C)574Djmo transgene
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:171645 Ramonet D, et al., Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2. PLoS One. 2011;6(4):e18568
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory