Tg(CAG-rtTA3)#Slowe
Transgene Detail

Summary

• Symbol: Tg(CAG-rtTA3)#Slowe
• Name: transgene insertion, Scott Lowe
• MGI ID: MGI:4950589
• Synonyms: CAG-rtTA3
• Transgene: Tg(CAG-rtTA3)#Slowe Location: unknown
• Alliance: Tg(CAG-rtTA3)#Slowe page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The CAG promoter drives ubiquitous expression of reverse tetracycline transactivator 3 with two mutations: 1) modified to bind to the tetracycline responsive element in the presence of doxycycline and 2) three mutations within the transactivator (S12G, F86Y, and A209T) that increase its sensitivity to doxycycline by 25-fold over the original rtTA without increasing background activity. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:171191)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:171191 Premsrirut PK, et al., A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell. 2011 Apr 1;145(1):145-58
• All: 9 reference(s)