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Grntm1.1Far
Targeted Allele Detail
Nomenclature
Symbol: Grntm1.1Far
Name: granulin; targeted mutation 1.1, Bob Farese
MGI ID: MGI:4949110
Synonyms: Grntm1.1Cke, Prgn-
Gene: Grn  Location: Chr11:102430322-102436809 bp, + strand  Genetic Position: Chr11, 66.29 cM
Increased total and phosphorylated TDP-43 in the cytoplasm of thalamic neurons in Grntm2.1Far/Grntm2.1Far and Grntm1.1Far/Grntm1.1Far mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170823
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLoxP sites were inserted flanking exons 2 to 13 and a neo cassette was inserted downstream of the polyadenylation signal via homologous recombination. Cre mediated recombination removed exons 2 to 13. Western blot analysis confirmed the absence of protein expression in peritoneal macrophages from homozygous mice. (J:170823)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grn Mutation:  31 strains or lines available
References
Original:  J:170823 Kao AW, et al., A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4441-6
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory