| Image |
|
||||||
| Caption | Increased total and phosphorylated TDP-43 in the cytoplasm of thalamic neurons in 12-month-old homozygous Grntm2.1Far/Grntm2.1Far (GrnR493X/R493X) and Grntm1.1Far/Grntm1.1Far (Grn-/-) mice. (A-C) Confocal microscopic images of thalamic neurons showed that TDP-43, detected by an N terminus antibody, was nearly exclusively in the nucleus of TuJ1+ neurons in wild-type (WT, Grn+/+) mice (A). (B) Compared with WT mice, thalamic neurons in age-matched Grntm2.1Far/Grntm2.1Far mice showed a significant increase of TDP-43 in the cytoplasm (indicated by the arrowheads). (C) A similar increase in cytoplasmic TDP-43 was detected in age-matched Grntm1.1Far/Grntm1.1Far thalamic neurons. (D-F) Confocal microscopic images of thalamic neurons showed no detectable p-TDP-43 in the nucleus or cytoplasm of neurons in WT mice (D). (E) Compared with WT mice, thalamic neurons in age-matched Grntm2.1Far/Grntm2.1Far mice showed a significant increase of p-TDP-43 in the cytoplasm (indicated by the arrowheads), but no detectable p-TDP43 in the nuclei. (F) A similar increase in cytoplasmic p-TDP-43 was detected in age-matched Grntm1.1Far/Grntm1.1Far thalamic neurons. (Scale bars, 20 um.) | ||||||
| Copyright | This image is from Nguyen AD, Proc Natl Acad Sci U S A 2018 Mar 20;115(12):E2849-E2858. Copyright 2018 National Academy of Sciences, U.S.A. J:259651 | ||||||
|
Associated Alleles |
|
||||||
|
Associated Genotypes |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/16/2024 MGI 6.23 |
|
|
|
||
Analysis Tools