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Ank1M1Wlst
Chemically induced Allele Detail
Nomenclature
Symbol: Ank1M1Wlst
Name: ankyrin 1, erythroid; Mutation 1, William L Stanford
MGI ID: MGI:4947988
Synonyms: Ank1E924X, ENU7192
Gene: Ank1  Location: Chr8:22974844-23150497 bp, + strand  Genetic Position: Chr8, 11.42 cM
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced a G to T transition in exon 27 that results in the amino acid substitution of a stop codon for glutamic acid at position 924 (E924X). Western blot analysis confirmed the expression of a truncated protein. (J:170562)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ank1 Mutation:  56 strains or lines available
References
Original:  J:170562 Hughes MR, et al., A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis. Exp Hematol. 2011 Mar;39(3):305-20, 320.e1-2
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory