All Phenotypes Ank1<M1Wlst> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ank1^M1Wlst/Ank1^M1Wlst	C3.B6-Ank1^M1Wlst	MGI:4948068
hm2	Ank1^M1Wlst/Ank1^M1Wlst	involves: 129S1/SvImJ * C3H/HeJ * C57BL/6	MGI:4948066
hm3	Ank1^M1Wlst/Ank1^M1Wlst	involves: C3H/HeJ * C57BL/6	MGI:4948064
ht4	Ank1^M1Wlst/Ank1⁺	C3.B6-Ank1^M1Wlst	MGI:4948067
ht5	Ank1^M1Wlst/Ank1⁺	involves: 129S1/SvImJ * C3H/HeJ * C57BL/6	MGI:4948065
ht6	Ank1^M1Wlst/Ank1⁺	involves: C3H/HeJ * C57BL/6	MGI:4948063

Allelic Composition	Ank1^M1Wlst/Ank1^M1Wlst
Genetic Background	C3.B6-Ank1^M1Wlst

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^M1Wlst mutation (0 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:170562 )

• no viable progeny are produced from crossing heterozygous mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:170562 )

• the mean lifespan of mice that survive to adulthood is 28 weeks

postnatal lethality, incomplete penetrance ( J:170562 )

• many jaundice mice die within 2 weeks of birth

hematopoietic system

enlarged spleen ( J:170562 )

• in adult mice

abnormal common myeloid progenitor cell morphology ( J:170562 )

• CFU-C progenitors are increased in the spleen and liver of adult mice compared to in wild-type mice

decreased common myeloid progenitor cell number ( J:170562 )

• total CFU-C, including and most severely affecting CFU-macrophage and CFU-granulocyte-macrophage progenitors, are reduced in the bone marrow of adult mice compared with wild-type mice

abnormal myelopoiesis ( J:170562 )

• mice exhibit myelodysplasia with increased CFU-progenitors in the adult spleen and liver compared with wild-type mice

extramedullary hematopoiesis ( J:170562 )

• profound in adult bone marrow, spleen, and liver

hemolytic anemia ( J:170562 )

• severe in adult mice

increased erythroid progenitor cell number ( J:170562 )

• adult mice exhibit a more than 10-fold increase in mature erythroblasts in the peripheral blood, doubling in the bone marrow, and a 25-fold increase in the spleen compared with wild-type mice

• CFU-E are increased 4-fold in the bone marrow and 125-fold in the spleen of adult mice

erythroblastosis ( J:170562 )

• in adult mice

abnormal erythrocyte morphology ( J:170562 )

• adult mice exhibit increased amorphous red blood cells, red cell fragments, and nucleated red blood cells compared with wild-type mice

decreased hematocrit ( J:170562 )

increased nucleated erythrocyte cell number ( J:170562 )

• in adult mice

polychromatophilia ( J:170562 )

• in adult mice

spherocytosis ( J:170562 )

• in adult mice

reticulocytosis ( J:170562 )

• in adult mice

growth/size/body

enlarged heart ( J:170562 )

• in adult mice

decreased birth weight ( J:170562 )

decreased body size ( J:170562 )

• mice that survive to weaning are runted compared with wild-type mice

decreased body weight ( J:170562 )

• in adult mice

postnatal growth retardation ( J:170562 )

decreased fetal weight ( J:170562 )

• at E17.5

enlarged spleen ( J:170562 )

• in adult mice

liver/biliary system

gallstones ( J:170562 )

• in adult mice

jaundice ( J:170562 )

• in some neonates

cardiovascular system

enlarged heart ( J:170562 )

• in adult mice

integument

pallor ( J:170562 )

• at E17.5

immune system

enlarged spleen ( J:170562 )

• in adult mice

abnormal myelopoiesis ( J:170562 )

• mice exhibit myelodysplasia with increased CFU-progenitors in the adult spleen and liver compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary spherocytosis type 1		DOID:0110916	OMIM:182900	J:170562

Allelic Composition	Ank1^M1Wlst/Ank1^M1Wlst
Genetic Background	involves: C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^M1Wlst mutation (0 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased erythrocyte cell number ( J:170562 )

decreased hematocrit ( J:170562 )

decreased hemoglobin content ( J:170562 )

decreased mean corpuscular hemoglobin concentration ( J:170562 )

decreased mean corpuscular volume ( J:170562 )

abnormal leukocyte cell number ( J:170562 )

immune system

abnormal leukocyte cell number ( J:170562 )

Allelic Composition	Ank1^M1Wlst/Ank1⁺
Genetic Background	C3.B6-Ank1^M1Wlst

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^M1Wlst mutation (0 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased erythrocyte cell number ( J:170562 )

decreased cellular hemoglobin content ( J:170562 )

decreased mean corpuscular hemoglobin concentration ( J:170562 )

decreased mean corpuscular volume ( J:170562 )

polychromatophilia ( J:170562 )

reticulocytosis ( J:170562 )

increased erythrocyte osmotic fragility ( J:170562 )

Allelic Composition	Ank1^M1Wlst/Ank1⁺
Genetic Background	involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^M1Wlst mutation (0 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:170562 )

abnormal erythrocyte morphology ( J:170562 )

• mice exhibit the same red blood cell phenotypes observed on a congenic C3H background

immune system

enlarged spleen ( J:170562 )

growth/size/body

enlarged spleen ( J:170562 )

Allelic Composition	Ank1^M1Wlst/Ank1⁺
Genetic Background	involves: C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^M1Wlst mutation (0 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased erythrocyte cell number ( J:170562 )

decreased cellular hemoglobin content ( J:170562 )

decreased mean corpuscular volume ( J:170562 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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