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Topbp1tm1.2Dsh
Targeted Allele Detail
Nomenclature
Symbol: Topbp1tm1.2Dsh
Name: topoisomerase (DNA) II binding protein 1; targeted mutation 1.2, Deog Su Hwang
MGI ID: MGI:4947432
Synonyms: TopBP1delta
Gene: Topbp1  Location: Chr9:103305215-103350428 bp, + strand  Genetic Position: Chr9, 55.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170406
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Cre-mediated recombination removed exons 5 and 6. (J:170406)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Topbp1 Mutation:  35 strains or lines available
References
Original:  J:170406 Jeon Y, et al., TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells. J Biol Chem. 2011 Feb 18;286(7):5414-22
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory