Phenotypes associated with this allele

• Allele Symbol: Topbp1^tm1.2Dsh
• Allele Name: targeted mutation 1.2, Deog Su Hwang
• Allele ID: MGI:4947432
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Topbp1^tm1.2Dsh/Topbp1^tm1.2Dsh	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * C57BL/6J	MGI:4947435

Genotype
MGI:4947435

hm1

• Allelic Composition: Topbp1^tm1.2Dsh/Topbp1^tm1.2Dsh
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality at implantation, complete penetrance ( J:170406 )

• mice die around implantation

cellular

increased embryonic tissue cell apoptosis ( J:170406 )

• E4.0 embryonic cells exhibit increased apoptosis compared with wild-type cells

decreased cell proliferation ( J:170406 )

• E4.5 embryonic cells fail to proliferate unlike wild-type cells

embryo

increased embryonic tissue cell apoptosis ( J:170406 )

• E4.0 embryonic cells exhibit increased apoptosis compared with wild-type cells

embryonic growth arrest ( J:170406 )

• cultured E3.5 embryos fail to grow beyond the point where wild-type embryos hatch