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Maoatm1Shih
Targeted Allele Detail
Nomenclature
Symbol: Maoatm1Shih
Name: monoamine oxidase A; targeted mutation 1, Jean C Shih
MGI ID: MGI:4946240
Synonyms: MAO-Aneo
Gene: Maoa  Location: ChrX:16619698-16687818 bp, + strand  Genetic Position: ChrX, 11.78 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:170067
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 12. A floxed neo cassette was inserted downstream of exon 12. No enzymatic activity was detected. Removal of the neo cassette is required to restore enzymatic activity. (J:170067, J:193013)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Maoa Mutation:  7 strains or lines available
References
Original:  J:170067 Kaludercic N, et al., Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload. Circ Res. 2010 Jan 8;106(1):193-202
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory