All Phenotypes Maoa<tm1Shih> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Maoa^tm1Shih
targeted mutation 1, Jean C Shih
MGI:4946240

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Maoa^tm1Shih/Maoa^tm1Shih	involves: 129S4/SvJae	MGI:4946255

Allelic Composition	Maoa^tm1Shih/Maoa^tm1Shih
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maoa^tm1Shih mutation (1 available); any Maoa mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased left ventricle systolic pressure ( J:170067 )

• before and after transverse aortic constriction

abnormal myocardial fiber physiology ( J:170067 )

• myocytes treated with norepinephrine exhibit reduced reactive oxygen species formation compared with similarly treated wild-type mice

decreased response of heart to induced stress ( J:170067 )

• at 9 weeks after transverse aortic constriction, mice exhibit improved left ventricular function, no chamber dilation, and reduced levels of fibrosis compared with wild-type mice

homeostasis/metabolism

decreased response of heart to induced stress ( J:170067 )

• at 9 weeks after transverse aortic constriction, mice exhibit improved left ventricular function, no chamber dilation, and reduced levels of fibrosis compared with wild-type mice

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