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Targeted Allele Detail
Symbol: Slc6a8tm1.1Clar
Name: solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1.1, Joseph Clark
MGI ID: MGI:4941753
Synonyms: CrTflox
Gene: Slc6a8  Location: ChrX:73673150-73682502 bp, + strand  Genetic Position: ChrX, 37.38 cM
Germline Transmission:  Earliest citation of germline transmission: J:169472
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette, leaving exons 2, 3, and 4 floxed. (J:169472)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a8 Mutation:  5 strains or lines available
Original:  J:169472 Skelton MR, et al., Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency. PLoS One. 2011;6(1):e16187
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory