Molecular Image Detail

Image

Caption

Generation of the Slc6a8^tm1Clar, Slc6a8^tm1.1Clar, and Slc6a8^tm1.2Clar alleles. (A) Strategy for recombination and deletion of Slc6a8. The structure of the wild-type Slc6a8 locus, the targeted locus after recombination in embryonic stem cells (Slc6a8^tm1Clar), and the floxed allele after Flp-mediated deletion of the neo cassette (Slc6a8^tm1.1Clar) are shown. Cre expression results in deletion of exons 2-4 (E2-E4) and generates the Slc6a8^tm1.2Clar allele. Exons are denoted by boxes; neo, loxP sequences, and FRT sequences are denoted by triangles.

This image is from Kurosawa Y, J Clin Invest 2012 Aug 1;122(8):2837-46 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190081

Associated
Alleles

Symbol	Name
Slc6a8^tm1.1Clar	solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1.1, Joseph Clark
Slc6a8^tm1.2Clar	solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1.2, Joseph Clark
Slc6a8^tm1Clar	solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1, Joseph Clark

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23