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Irf8tm1.1Hm
Targeted Allele Detail
Nomenclature
Symbol: Irf8tm1.1Hm
Name: interferon regulatory factor 8; targeted mutation 1.1, Herbert Morse III
MGI ID: MGI:4939593
Synonyms: Irf8f
Gene: Irf8  Location: Chr8:120736358-120756694 bp, + strand  Genetic Position: Chr8, 70.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168923
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 2 was floxed. The FRT-flanked neo cassette used for selection was removed by flp-mediated recombination. (J:168923)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf8 Mutation:  9 strains or lines available
References
Original:  J:168923 Feng J, et al., IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools. J Immunol. 2011 Feb 1;186(3):1458-66
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory