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Rhebl1tm1.1Pfw
Targeted Allele Detail
Nomenclature
Symbol: Rhebl1tm1.1Pfw
Name: Ras homolog enriched in brain like 1; targeted mutation 1.1, Paul Worley
MGI ID: MGI:4939475
Synonyms: Rheb2-
Gene: Rhebl1  Location: Chr15:98877778-98881404 bp, - strand  Genetic Position: Chr15, 54.99 cM, cytoband F2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168571
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into the 5'UTR region of exon 1 and an FRT flanked PGK-neo cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed part of exon 1, all of exon 2 and the neo cassette. (J:168571)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rhebl1 Mutation:  10 strains or lines available
References
Original:  J:168571 Zou J, et al., Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell. 2011 Jan 18;20(1):97-108
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory