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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rhebl1tm1.1Pfw
targeted mutation 1.1, Paul Worley
MGI:4939475
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw involves: C57BL/6 MGI:4939485
cx2
 		Rhebtm1.1Pfw/Rhebtm1.1Pfw
Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw 		involves: C57BL/6 MGI:4939478
cx3
 		Rhebtm1.1Pfw/Rheb+
Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw 		involves: C57BL/6 MGI:4939479


Genotype
MGI:4939485
hm1
Allelic
Composition		 Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhebl1tm1.1Pfw mutation (0 available); any Rhebl1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:168571 )
• viable and fertile with no obvious defects




Genotype
MGI:4939478
cx2
Allelic
Composition		 Rhebtm1.1Pfw/Rhebtm1.1Pfw
Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhebl1tm1.1Pfw mutation (0 available); any Rhebl1 mutation (17 available)
Rhebtm1.1Pfw mutation (0 available); any Rheb mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:168571 )
• similar to mice homozygous for the Rheb allele alone




Genotype
MGI:4939479
cx3
Allelic
Composition		 Rhebtm1.1Pfw/Rheb+
Rhebl1tm1.1Pfw/Rhebl1tm1.1Pfw
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhebl1tm1.1Pfw mutation (0 available); any Rhebl1 mutation (17 available)
Rhebtm1.1Pfw mutation (0 available); any Rheb mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:168571 )
N
• unlike double homozygous mice, mice with one wild-type allele of Rheb are viable




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory