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Mecp2tm3.1Bird
Targeted Allele Detail
Nomenclature
Symbol: Mecp2tm3.1Bird
Name: methyl CpG binding protein 2; targeted mutation 3.1, Adrian Bird
MGI ID: MGI:4938309
Synonyms: MECP2-EGFP
Gene: Mecp2  Location: ChrX:74026592-74085690 bp, - strand  Genetic Position: ChrX, 37.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168822
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsA targeting construct was designed to insert an enhanced green fluorescent protein sequence (EGFP) sequence (preceded by sequence for linker peptide CKDPPVAT) and a loxP-flanked neomycin (neo) resistance sequence-STOP cassette in the 3' UTR. Subsequent cre-mediated recombination removed the floxed neo-STOP cassette. This allele expresses a chimeric protein with the EGFP peptide linked to the C-terminus of the endogenous peptide. (J:168822)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:  23 strains or lines available
References
Original:  J:168822 Bird A, Direct Data Submission 2011/02/25. MGI Direct Data Submission. 2011;
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory