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Atrxtm1Enl
Targeted Allele Detail
Nomenclature
Symbol: Atrxtm1Enl
Name: ATRX, chromatin remodeler; targeted mutation 1, En Li
MGI ID: MGI:4888669
Synonyms: ATRXdeltaE2, Atrxtm1Ikit
Gene: Atrx  Location: ChrX:104841221-104972978 bp, - strand  Genetic Position: ChrX, 47.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168608
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a splice acceptor and IRES-beta-geo cassette. The reduction in protein expression was confirmed by western blot analysis on brain extracts. (J:168608)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atrx Mutation:  81 strains or lines available
References
Original:  J:168608 Nogami T, et al., Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice. Hippocampus. 2011 Jun;21(6):678-87
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory