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Ucp2tm2.1Lowl
Targeted Allele Detail
Nomenclature
Symbol: Ucp2tm2.1Lowl
Name: uncoupling protein 2 (mitochondrial, proton carrier); targeted mutation 2.1, Bradford B Lowell
MGI ID: MGI:4887236
Synonyms: Ucp2lox
Gene: Ucp2  Location: Chr7:100493337-100502020 bp, + strand  Genetic Position: Chr7, 54.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167906
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting construct was used to introduce loxP sites into intron 2 and intron 6 of Ucp2, as well as an FRT-flanked kanamycin selection cassette. Homologous recombination in W4 ES cells was used to generate the floxed allele. Chimeras were bred to Flp recombinase expressing mice to remove the selection marker cassette. (J:167906)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ucp2 Mutation:  25 strains or lines available
References
Original:  J:167906 Kong D, et al., Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab. 2010 Nov 3;12(5):545-52
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory