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Targeted Allele Detail
Symbol: Ucp2tm2.1Lowl
Name: uncoupling protein 2 (mitochondrial, proton carrier); targeted mutation 2.1, Bradford B Lowell
MGI ID: MGI:4887236
Synonyms: Ucp2lox
Gene: Ucp2  Location: Chr7:100493337-100502020 bp, + strand  Genetic Position: Chr7, 54.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:167906
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting construct was used to introduce loxP sites into intron 2 and intron 6 of Ucp2, as well as an FRT-flanked kanamycin selection cassette. Homologous recombination in W4 ES cells was used to generate the floxed allele. Chimeras were bred to Flp recombinase expressing mice to remove the selection marker cassette. (J:167906)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ucp2 Mutation:  29 strains or lines available
Original:  J:167906 Kong D, et al., Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab. 2010 Nov 3;12(5):545-52
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
The Jackson Laboratory