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Ackr3tm1.1Twb
Targeted Allele Detail
Nomenclature
Symbol: Ackr3tm1.1Twb
Name: atypical chemokine receptor 3; targeted mutation 1.1, Timothy Behrens
MGI ID: MGI:4881712
Synonyms: Ackr3tm1.1Dsr, Cxcr7-
Gene: Ackr3  Location: Chr1:90203980-90215724 bp, + strand  Genetic Position: Chr1, 45.28 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:167833
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2 and the neo cassette. (J:167833)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 15 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ackr3 Mutation:  13 strains or lines available
References
Original:  J:167833 Yu S, et al., The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Dev Dyn. 2011 Feb;240(2):384-93
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory