Opn4tm1.1(cre)Saha
Targeted Allele Detail
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Symbol: |
Opn4tm1.1(cre)Saha |
Name: |
opsin 4 (melanopsin); targeted mutation 1.1, Samer Hattar |
MGI ID: |
MGI:4881482 |
Synonyms: |
Opn4Cre |
Gene: |
Opn4 Location: Chr14:34312575-34322099 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
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Alliance: |
Opn4tm1.1(cre)Saha page
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Germline Transmission: |
Earliest citation of germline transmission:
J:167871
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Recombinase) |
Mutations: |
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Insertion, Intragenic deletion
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Opn4tm1.1(cre)Saha expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: Cre recombinase preceded by a human beta-globin intron and nuclear localization signal was inserted immediately after the start codon of the Opn4 gene, replacing the open reading frame. An FRT-flanked pgk-neo cassette followed the cre coding sequence. Homologous recombination in ES cells resulted in replacement of the coding region of Opn4 with this construct. After establishing germline transmission of the allele, mice were crossed to Flp-expressing animals to remove the neo cassette with the Flp gene subsequently bred out of the line in creating homozygous mutants.
(J:167871)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Opn4
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Opn4 Mutation: |
33 strains or lines available
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Original: |
J:167871 Ecker JL, et al., Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron. 2010 Jul 15;67(1):49-60 |
All: |
51 reference(s) |
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