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Targeted Allele Detail
Symbol: Cxcr4tm3.1Yzo
Name: chemokine (C-X-C motif) receptor 4; targeted mutation 3.1, Yong-Rui Zou
MGI ID: MGI:4878934
Synonyms: CXCR4deltaT
Gene: Cxcr4  Location: Chr1:128588199-128592293 bp, - strand  Genetic Position: Chr1, 56.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:167314
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 1. Cre mediated recombination removed the neo cassette and exon 2. (J:167314)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cxcr4 Mutation:  10 strains or lines available
Original:  J:167314 Cronshaw DG, et al., An essential role of the cytoplasmic tail of CXCR4 in g-protein signaling and organogenesis. PLoS One. 2010;5(11):e15397
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory