Tgm2^tm1Syki
Targeted Allele Detail

Summary

• Symbol: Tgm2^tm1Syki
• Name: transglutaminase 2, C polypeptide; targeted mutation 1, Soo-Youl Kim
• MGI ID: MGI:4868708
• Gene: Tgm2 Location: Chr2:157958325-157988312 bp, - strand Genetic Position: Chr2, 78.72 cM
• Alliance: Tgm2^tm1Syki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167049
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 and 6 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis. (J:167049)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgm2 Mutation: 49 strains or lines available

References

• Original: J:167049 Kim DS, et al., Transglutaminase 2 gene ablation protects against renal ischemic injury by blocking constant NF-kappaB activation. Biochem Biophys Res Commun. 2010 Dec 17;403(3-4):479-84
• All: 8 reference(s)