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Il6ratm1.1Jcbr
Targeted Allele Detail
Nomenclature
Symbol: Il6ratm1.1Jcbr
Name: interleukin 6 receptor, alpha; targeted mutation 1.1, Jens Bruning
MGI ID: MGI:4847943
Synonyms: Il6-RalphaFL
Gene: Il6ra  Location: Chr3:89869324-89913196 bp, - strand  Genetic Position: Chr3, 39.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166367
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2, and an additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette leaving exons 2 and 3 floxed. (J:166367)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il6ra Mutation:  23 strains or lines available
References
Original:  J:166367 Wunderlich FT, et al., Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab. 2010 Sep 8;12(3):237-49
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory