Adarb1^tm1.1Skwa
Targeted Allele Detail

Summary

• Symbol: Adarb1^tm1.1Skwa
• Name: adenosine deaminase, RNA-specific, B1; targeted mutation 1.1, Shin Kwak
• MGI ID: MGI:4840554
• Synonyms: ADAR2^flox
• Gene: Adarb1 Location: Chr10:77126560-77254104 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C
• Alliance: Adarb1^tm1.1Skwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164294
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 7 and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the neo cassette leaving exons 7 through 9 floxed. (J:164294)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adarb1 Mutation: 35 strains or lines available

References

• Original: J:164294 Hideyama T, et al., Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2. J Neurosci. 2010 Sep 8;30(36):11917-25
• All: 9 reference(s)