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Adarb1tm1.1Skwa
Targeted Allele Detail
Nomenclature
Symbol: Adarb1tm1.1Skwa
Name: adenosine deaminase, RNA-specific, B1; targeted mutation 1.1, Shin Kwak
MGI ID: MGI:4840554
Synonyms: ADAR2flox
Gene: Adarb1  Location: Chr10:77290726-77418270 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164294
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 7 and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the neo cassette leaving exons 7 through 9 floxed. (J:164294)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adarb1 Mutation:  8 strains or lines available
References
Original:  J:164294 Hideyama T, et al., Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2. J Neurosci. 2010 Sep 8;30(36):11917-25
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory