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Adgra2tm1Cjku
Targeted Allele Detail
Summary
Symbol: Adgra2tm1Cjku
Name: adhesion G protein-coupled receptor A2; targeted mutation 1, Calvin J Kuo
MGI ID: MGI:4840264
Synonyms: GPR124lacZ
Gene: Adgra2  Location: Chr8:27575611-27613464 bp, + strand  Genetic Position: Chr8, 15.91 cM, cytoband A3
Alliance: Adgra2tm1Cjku page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166127
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first coding exon was replaced with a lacZ/neo cassette. Quantitative RT-PCR, northern and western blot analysis confirmed the absence of RNA and protein expression in homozygous embryos. LacZ expression is detected in the vasculature in heterozygous embryos at E10.5. (J:166127)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adgra2 Mutation:  43 strains or lines available
References
Original:  J:166127 Kuhnert F, et al., Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science. 2010 Nov 12;330(6006):985-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory