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Rapgef2tm1.1Hous
Targeted Allele Detail
Nomenclature
Symbol: Rapgef2tm1.1Hous
Name: Rap guanine nucleotide exchange factor (GEF) 2; targeted mutation 1.1, Steven X Hou
MGI ID: MGI:4839105
Synonyms: RapGEF2cko
Gene: Rapgef2  Location: Chr3:79062516-79286517 bp, - strand  Genetic Position: Chr3, 34.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:165879
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 4 (originally numbered as exon 18) and an FRT and loxP flanked neo cassette was inserted downstream of exon 18. Flp mediated recombination removed the neo cassette leaving exon 18 floxed. (J:165879, J:255838)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rapgef2 Mutation:  48 strains or lines available
References
Original:  J:165879 Satyanarayana A, et al., RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood. 2010 Oct 21;116(16):2921-31
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory