Fbn1^tm2.1Lysa
Targeted Allele Detail

Summary

• Symbol: Fbn1^tm2.1Lysa
• Name: fibrillin 1; targeted mutation 2.1, Lynn Y Sakai
• MGI ID: MGI:4839071
• Synonyms: H1delta
• Gene: Fbn1 Location: Chr2:125142514-125348417 bp, - strand Genetic Position: Chr2, 61.38 cM, cytoband F
• Alliance: Fbn1^tm2.1Lysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165897
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Hypomorph) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 7 and an FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 7. Cre mediated recombination removed the neo cassette and exon 7. The predicted product lacks the hybrid 1 domain. (J:165897)

Generation of the Fbn1^tm2.1Lysa allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbn1 Mutation: 171 strains or lines available

References

• Original: J:165897 Charbonneau NL, et al., In vivo studies of mutant fibrillin-1 microfibrils. J Biol Chem. 2010 Aug 6;285(32):24943-55
• All: 2 reference(s)