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Targeted Allele Detail
Symbol: Stk39tm1.2Slin
Name: serine/threonine kinase 39; targeted mutation 1.2, Shih-Hua Lin
MGI ID: MGI:4838422
Gene: Stk39  Location: Chr2:68210445-68472268 bp, - strand  Genetic Position: Chr2, 39.53 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:165706
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsOne loxP site was inserted just 5' of exon 9 and an FRT flanked neomycin selection cassette was placed in intron 10 followed by a second loxP site. The selection cassette was subsequently excised from properly targeted ES cells usin flp recombinase, leaving exons 9 and 10 flanked by loxP sites. Mice were then crossed to transgenic mice expressing Tg(CAG-cre)13Miya to delete exons 9 and 10. (J:165706)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk39 Mutation:  10 strains or lines available
Original:  J:165706 Yang SS, et al., SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol. 2010 Nov;21(11):1868-77
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory