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Pip5k1ctm1.2Ref
Targeted Allele Detail
Nomenclature
Symbol: Pip5k1ctm1.2Ref
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma; targeted mutation 1.2, Reinhard Fassler
MGI ID: MGI:4838023
Synonyms: PIPKIgamma90-, PIPKIgammadeltaE17
Gene: Pip5k1c  Location: Chr10:81292963-81319973 bp, + strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164732
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted
Mutation:    Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 17. An FRT-flanked neomycin resistance cassette with a 3' loxP site was insserted downstream of exon 17. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed the neomycin resistance cassette. The absence of isoform 1 protein expression was confirmed by western blot analysis on T cell extracts. (J:180016)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pip5k1c Mutation:  6 strains or lines available
References
Original:  J:164732 Wernimont SA, et al., PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells. J Immunol. 2010 Oct 15;185(8):4714-23
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory