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Targeted Allele Detail
Symbol: Sp8tm2Smb
Name: trans-acting transcription factor 8; targeted mutation 2, Sheila M Bell
MGI ID: MGI:4837153
Synonyms: Sp8flox
Gene: Sp8  Location: Chr12:118810064-118816311 bp, + strand  Genetic Position: Chr12, 63.48 cM
Germline Transmission:  Earliest citation of germline transmission: J:86196
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT flanked neomycin selection cassette and a 5' loxP site were inserted in intron 2. A second loxP site was placed downstream of the zinc finger domain and stop codon in the 3' UTR. The coding sequence of the gene was thus surrounded by loxP sites. Sp8tm1Smb was derived from this allele. (J:86196)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sp8 Mutation:  24 strains or lines available
Original:  J:86196 Bell SM, et al., Sp8 is crucial for limb outgrowth and neuropore closure. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12195-200
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory