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Cxcr4tm1Yiw
Targeted Allele Detail
Nomenclature
Symbol: Cxcr4tm1Yiw
Name: chemokine (C-X-C motif) receptor 4; targeted mutation 1, Yoichiro Iwakura
MGI ID: MGI:4836915
Synonyms: Cxcr4flox
Gene: Cxcr4  Location: Chr1:128515936-128520030 bp, - strand  Genetic Position: Chr1, 56.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164872
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 2 was floxed and a neomycin resistant cassette was inserted 5' to the second loxP site within intron 2. (J:164872)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Cxcr4 Mutation:  32 strains or lines available
References
Original:  J:164872 Chung SH, et al., CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis. Arthritis Res Ther. 2010 Oct 12;12(5):R188
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory