Phenotypes associated with this allele

• Allele Symbol: Cxcr4^tm1Yiw
• Allele Name: targeted mutation 1, Yoichiro Iwakura
• Allele ID: MGI:4836915
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cxcr4^tm1Yiw/Cxcr4^tm1Yiw Tg(Lck-cre)1Jtak/0	involves: 129P2/OlaHsd	MGI:4836916

Genotype
MGI:4836916

cn1

• Allelic Composition: Cxcr4^tm1Yiw/Cxcr4^tm1Yiw; Tg(Lck-cre)1Jtak/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal leukocyte migration ( J:164872 )

• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers

decreased thymocyte number ( J:164872 )

• thymocytes numbers are significantly reduced

immune system

abnormal leukocyte migration ( J:164872 )

• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers

decreased thymocyte number ( J:164872 )

• thymocytes numbers are significantly reduced

decreased susceptibility to induced arthritis ( J:164872 )

• the incidence, but not the severity, of collagen induced arthritis is significantly reduced

skeleton

decreased susceptibility to induced arthritis ( J:164872 )

• the incidence, but not the severity, of collagen induced arthritis is significantly reduced

cellular

abnormal leukocyte migration ( J:164872 )

• impaired T cell chemotaxis to CXCL12 as measured using chemotaxis chambers

endocrine/exocrine glands

decreased thymocyte number ( J:164872 )

• thymocytes numbers are significantly reduced