Igh^tm5.1Cog
Targeted Allele Detail

Summary

• Symbol: Igh^tm5.1Cog
• Name: immunoglobulin heavy chain complex; targeted mutation 5.1, Michel Cogne
• MGI ID: MGI:4836663
• Synonyms: delta3'RR, IgH 3'RR^-, IgH a^delta3'RR, Rr152^tm5.1Cog
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164513
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site flanked neomycin resistance gene cassette replaced the entire 3' regulatory region (3'RR, located downstream of the Ighc gene segments)(Rr152), which contains the enhancers hs3a (Rr154), hs1,2 (Rr153), hs3b (Rr155) and hs4 (Rr156). Cre-mediated recombination removed the neo cassette. (J:164513)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 43 strains or lines available

References

• Original: J:164513 Vincent-Fabert C, et al., Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes. Blood. 2010 Sep 16;116(11):1895-8
• All: 18 reference(s)