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Tg(Adipoq-cre)1Evdr
Transgene Detail
Nomenclature
Symbol: Tg(Adipoq-cre)1Evdr
Name: transgene insertion 1, Evan Rosen
MGI ID: MGI:4836360
Synonyms: A-Cre, Adipoq-Cre, Adn-Cre, Tg(Adipoq-CreERT2)tm1Jgg
Transgene: Tg(Adipoq-cre)1Evdr  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/NJ
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsTo generate the Adipoq-Cre BAC transgenic mice, the 245 kb RP23-90G21 bacterial artificial chromosome (BAC) containing at least five mouse genes was modified by replacing the starting ATG and 222 bp of the adiponectin gene with the starting ATG and coding sequence of a Cre recombinase gene. Founder line 1 was analyzed. These mice express Cre recombinase effectively in white adipose tissue (WAT) and brown adipose tissue (BAT), but not in macrophages (including adipose-tissue resident macrophages, alveolar macrophages, or thioglycollate-stimulated peritoneal macrophages). The donating investigator reports highly efficient Cre recombinase activity, with no ectopic expression. (J:168971)
Recombinase
activity
Activity:
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Driver: Adipoq     Summary of all recombinase alleles driven by Adipoq. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:168971 Eguchi J, et al., Transcriptional Control of Adipose Lipid Handling by IRF4. Cell Metab. 2011 Mar 2;13(3):249-59
All:  211 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory