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Tg(ACTA1-cre)AMcle
Transgene Detail
Nomenclature
Symbol: Tg(ACTA1-cre)AMcle
Name: transgene insertion A, Ian S McLennan
MGI ID: MGI:4833970
Synonyms: MuCr-A, MuCreA, MuCre-A
Transgene: Tg(ACTA1-cre)AMcle  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe human alpha skeletal muscle actin (ACTA1) promoter was used to drive expression of cre recombinase in a transgenic construct. The construct was injected into C57BL/6 zygotes. 14 founders were generated, and two lines were characterized further. Lines A and B were analyzed. Cre expression was observed in skeletal muscle as well as in the heart, with line A exhibiting 40% of the level of cre mRNA detected in skeletal muscle, and line B showing 0.1% of skeletal muscle cre mRNA levels in the heart muscle. (J:164492)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: ACTA1 (human) Summary of all recombinase alleles driven by ACTA1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:164492 Azhar M, et al., Myocardial deletion of Smad4 using a novel alpha skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract. Int J Biol Sci. 2010;6(6):546-55
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory