Eif4e^tm1.1Lfur
Targeted Allele Detail

Summary

• Symbol: Eif4e^tm1.1Lfur
• Name: eukaryotic translation initiation factor 4E; targeted mutation 1.1, Luc Furic
• MGI ID: MGI:4830310
• Synonyms: eIF4E^S209A, eIF4E^Ser209Ala
• Gene: Eif4e Location: Chr3:138231952-138265457 bp, + strand Genetic Position: Chr3, 64.3 cM
• Alliance: Eif4e^tm1.1Lfur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163589
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 8 was replaced with one in which nucleotide substitutions result in the amino acid substitution of alanine for serine at position 209 (S209A). A floxed neo cassette inserted upstream of the modified exon was removed by cre mediated recombination. (J:163589)

Tumor Data

List all tumor models in MMHCdb carrying Eif4e^tm1.1Lfur

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif4e Mutation: 42 strains or lines available

References

• Original: J:163589 Furic L, et al., eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14134-9
• All: 21 reference(s)