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Del(6Slco1b2-Slco1a5)1Nki
Targeted Allele Detail
Nomenclature
Symbol: Del(6Slco1b2-Slco1a5)1Nki
Name: deletion, Chr 6, the Netherlands Cancer Institute 1; deletion, Chr 6, The Netherlands Cancer Institute
MGI ID: MGI:4830091
Synonyms: Del1Nki, Del(6)2Ahs, Del(6Gm5724-Slco1a6)2Ahs, Del(6Slco1b2-Slco1a5)2Ahs, Slco1a/1b-
Gene: Del(6Slco1b2-Slco1a5)1Nki  Location: Chr6:141575244-142268707 bp  Genetic Position: Chr6, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163765
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(6Slco1b2-Slco1a5)1Nki involves 13 genes/genome features (Gm23069, Gm23775, Gm22036 ...) View all
 
Mutation detailsExons 3 and 4 of Slco1a5 were replaced with floxed neo cassette while exon 4 in Slco1b2 was replaced with a Pgk-thymidine kinase and floxed Pgk-hygro cassette. Cre mediated recombination remove the intervening sequence (including Gm5724, Slco1a4, Slco1a1, Gm6614, and Slco1a6). The absence of transcript expression was confirmed by RT-PCR on liver, kidney, and small intestine extracts. (J:163765)
Generation of the Del(6Slco1b2-Slco1a5)1Nki allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(6Slco1b2-Slco1a5)1Nki Mutation:  0 strains or lines available
References
Original:  J:163765 van de Steeg E, et al., Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J Clin Invest. 2010 Aug 2;120(8):2942-52
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory