Del(6Slco1b2-Slco1a5)1Nki Cytogenetic Marker Detail

Summary

• Symbol
  Del(6Slco1b2-Slco1a5)1Nki
• Name
  deletion, Chr 6, the Netherlands Cancer Institute 1
• Synonyms
  Del(6Gm5724-Slco1a6)2Ahs, Del(6Slco1b2-Slco1a5)2Ahs

• Feature Type
  chromosomal deletion
• IDs
  MGI:4830136

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 6, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotypes from 1 allele in 1 genetic background
  12 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for this deletion exhibit increased circulating conjugated and non-conjugated bilirubin levels and abnormal methotrexate and fexofenadine pharmacokinetics.

Other
Accession IDs

MGI:6161376

References

• Summaries
  All 13

  Phenotypes 12
• Earliest
  J:163765 van de Steeg E, et al., Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J Clin Invest. 2010 Aug 2;120(8):2942-52
• Latest
  J:390393 Richter FC, et al., Crosstalk between CD8+ T cells and systemic bile acid metabolism shapes antiviral immunity and immunopathology. JCI Insight. 2026 Jun 22;11(12)