About   Help   FAQ
Stim1tm1.1Kuro
Targeted Allele Detail
Summary
Symbol: Stim1tm1.1Kuro
Name: stromal interaction molecule 1; targeted mutation 1.1, Tomohiro Kurosaki
MGI ID: MGI:4821943
Gene: Stim1  Location: Chr7:101917013-102086526 bp, + strand  Genetic Position: Chr7, 54.71 cM
Alliance: Stim1tm1.1Kuro page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130477
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette was inserted in intron 5 and a third loxP site was inserted downstream of exon 6. Mice were crossed with a CAG-cre transgenic mouse to excise both the floxed neomycin cassette and exon 6. Immunoblots of extracts from liver derived mast cells failed to detect protein product. (J:130477)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stim1 Mutation:  46 strains or lines available
References
Original:  J:130477 Baba Y, et al., Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses. Nat Immunol. 2008 Jan;9(1):81-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory