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Targeted Allele Detail
Symbol: Stim1tm1.1Kuro
Name: stromal interaction molecule 1; targeted mutation 1.1, Tomohiro Kurosaki
MGI ID: MGI:4821943
Gene: Stim1  Location: Chr7:102267806-102437319 bp, + strand  Genetic Position: Chr7, 54.71 cM
Germline Transmission:  Earliest citation of germline transmission: J:130477
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neomycin resistance cassette was inserted in intron 5 and a third loxP site was inserted downstream of exon 6. Mice were crossed with a CAG-cre transgenic mouse to excise both the floxed neomycin cassette and exon 6. Immunoblots of extracts from liver derived mast cells failed to detect protein product. (J:130477)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stim1 Mutation:  22 strains or lines available
Original:  J:130477 Baba Y, et al., Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses. Nat Immunol. 2008 Jan;9(1):81-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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