Phenotypes associated with this allele

• Allele Symbol: Stim1^tm1.1Kuro
• Allele Name: targeted mutation 1.1, Tomohiro Kurosaki
• Allele ID: MGI:4821943
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stim1^tm1.1Kuro/Stim1^tm1.1Kuro	C57BL/6-Stim1^tm1.1Kuro	MGI:4821950
ht2	Stim1^tm1.1Kuro/Stim1^+	C57BL/6-Stim1^tm1.1Kuro	MGI:4821952

Genotype
MGI:4821950

hm1

• Allelic Composition: Stim1^tm1.1Kuro/Stim1^tm1.1Kuro
• Genetic Background: C57BL/6-Stim1^tm1.1Kuro

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:130477 )

• mice die perinatally

• embryos are apparently normal at E18.5

growth/size/body

decreased birth body size ( J:130477 )

• mice born alive are slightly reduced in size

respiratory system

respiratory failure ( J:130477 )

• mice born alive die within 1 day of apparent respiratory failure

immune system

decreased mast cell degranulation ( J:130477 )

• liver mast cell degranulation induced by ionomycin is reduced

abnormal cytokine secretion ( J:130477 )

abnormal interleukin secretion ( J:130477 )

decreased interleukin-13 secretion ( J:130477 )

• by liver mast cells

decreased interleukin-6 secretion ( J:130477 )

• by liver mast cells

decreased tumor necrosis factor secretion ( J:130477 )

• by liver mast cells

hematopoietic system

decreased mast cell degranulation ( J:130477 )

• liver mast cell degranulation induced by ionomycin is reduced

cellular

decreased mast cell degranulation ( J:130477 )

• liver mast cell degranulation induced by ionomycin is reduced

Genotype
MGI:4821952

ht2

• Allelic Composition: Stim1^tm1.1Kuro/Stim1⁺
• Genetic Background: C57BL/6-Stim1^tm1.1Kuro

immune system

decreased susceptibility to type I hypersensitivity reaction ( J:130477 )

• passive cutaneous anaphylaxis is reduced