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Gckm1Rge
Chemically induced Allele Detail
Nomenclature
Symbol: Gckm1Rge
Name: glucokinase; ENU mutation 1, University of Munich
MGI ID: MGI:4820836
Synonyms: GLS001, Munich GckM210R
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Mutation
origin
Strain of Origin:  C3HeB/FeJ
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced a G to T transition at position 629 in exon 6 (NCBI GenBank accession no. NM_010292). This point mutation results in an amino acid substitution of arginine for methionine at position 210 (M210R). (J:162903)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  37 strains or lines available
References
Original:  J:162903 van Burck L, et al., Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2). Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E512-23
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/19/2018
MGI 6.12
The Jackson Laboratory