Phenotypes associated with this allele

• Allele Symbol: Gck^m1Rge
• Allele Name: ENU mutation 1, University of Munich
• Allele ID: MGI:4820836
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gck^m1Rge/Gck^m1Rge	involves: C3HeB/FeJ	MGI:4820840
ht2	Gck^m1Rge/Gck^+	involves: C3HeB/FeJ	MGI:4820839

Genotype
MGI:4820840

hm1

• Allelic Composition: Gck^m1Rge/Gck^m1Rge
• Genetic Background: involves: C3HeB/FeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:162903 )

• mice die of severe diabetes mellitus no later than P6

homeostasis/metabolism

hyperglycemia ( J:162903 )

• dramatically at P1

increased urine glucose level ( J:162903 )

• P1

growth/size/body

decreased body weight ( J:162903 )

• at P4

postnatal growth retardation ( J:162903 )

renal/urinary system

increased urine glucose level ( J:162903 )

• P1

Genotype
MGI:4820839

ht2

• Allelic Composition: Gck^m1Rge/Gck⁺
• Genetic Background: involves: C3HeB/FeJ

homeostasis/metabolism

decreased insulin secretion ( J:162903 )

• marginally in beta cells of male mice

hyperglycemia ( J:162903 )

• slightly in fed mice from the first days of life

• significantly at 30 days of age

• at 30 days during a glucose tolerance test

increased circulating insulin level ( J:162903 )

• in fasted male mice and after oral glucose administration at 90 and 180 days

impaired glucose tolerance ( J:162903 )

insulin resistance ( J:162903 )

• slightly in male mice

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:162903 )

• in male, but not female, mice

small pancreatic islets ( J:162903 )

• in male, but not female, mice

decreased insulin secretion ( J:162903 )

• marginally in beta cells of male mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:162903