Ifi202b^tm1(KOMP)Mbp
Targeted Allele Detail

Summary

• Symbol: Ifi202b^tm1(KOMP)Mbp
• Name: interferon activated gene 202B; targeted mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:4820026
• Synonyms: IFI202 KO
• Gene: Ifi202b Location: Chr1:173790134-173810310 bp, - strand Genetic Position: Chr1, 80.79 cM
• Alliance: Ifi202b^tm1(KOMP)Mbp page
• IMPC: Ifi202b gene page

Mutation origin

• Mutant Cell Lines: DEPD00527_1_A05, DEPD00527_1_A07, DEPD00527_1_A08, DEPD00527_1_B06, DEPD00527_1_B08, DEPD00527_1_C05, DEPD00527_1_C06, DEPD00527_1_C07, DEPD00527_1_C08, DEPD00527_1_D05, DEPD00527_1_D06, DEPD00527_1_D07, DEPD00527_1_D08, DEPD00527_1_E05, DEPD00527_1_F07, DEPD00527_1_G05, DEPD00527_1_G07, DEPD00527_1_G08, DEPD00527_1_H05, DEPD00527_1_H06, DEPD00527_1_H07
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 886 starting at position 173802181 and ending at position 173803067 of Chromosome 1 (Genome Build GRCm39). This deletion results in the removal of the functionally critical exon 3. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. This allele generates a protein predicted to contain a portion of the HIN-A domain and a full HIN-B domain. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Ifi202b Mutation: 19 strains or lines available

References

• Original: J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010
• All: 3 reference(s)