Tg(Lck-LMO1)11Sjk
Transgene Detail

Summary

• Symbol: Tg(Lck-LMO1)11Sjk
• Name: transgene insertion 11, Stanley J Korsmeyer
• MGI ID: MGI:4819166
• Synonyms: lck-LMO1, lck^Pr Ttg-1, LMO1^tg
• Transgene: Tg(Lck-LMO1)11Sjk Location: unknown
• Alliance: Tg(Lck-LMO1)11Sjk page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-LMO1)11Sjk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LMO1 (4004)

  Lmo1	(MGI:102812)

• Tg(Lck-LMO1)11Sjk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lck (MGI:96756)

• Mutation details: The mouse proximal promoter drives T cell-specific expression of the human cDNA. Four lines were established (5, 11, 18, and 24). (J:2066)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:2066 McGuire EA, et al., Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma. Mol Cell Biol. 1992 Sep;12(9):4186-96
• All: 7 reference(s)