About   Help   FAQ
Hoxc8tm2.1(cre)Mrc
Targeted Allele Detail
Nomenclature
Symbol: Hoxc8tm2.1(cre)Mrc
Name: homeobox C8; targeted mutation 2.1, Mario R Capecchi
MGI ID: MGI:4818428
Synonyms: C8cre, Hoxc8-ICre
Gene: Hoxc8  Location: Chr15:102990607-102994111 bp, + strand  Genetic Position: Chr15, 58.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:162102
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA fragment consisting of cre recombinase preceded by an internal ribosomal entry site (IRES) and followed by an FRT-neo-FRT cassette was inserted into the 3' UTR of exon 2 of Hoxc8. The neomycin cassette was subsequently removed by breeding with FLPe deleter animals. (J:162102)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hoxc8     Summary of all recombinase alleles driven by Hoxc8. Comparative matrix view of recombinase activities
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxc8 Mutation:  0 strains or lines available
References
Original:  J:162102 Chen SK, et al., Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell. 2010 May 28;141(5):775-85
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/05/2019
MGI 6.14
The Jackson Laboratory