Phenotypes associated with this allele

• Allele Symbol: Hoxc8^{tm2.1(cre)Mrc}
• Allele Name: targeted mutation 2.1, Mario R Capecchi
• Allele ID: MGI:4818428
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hoxb8^tm3.1(IRES-rtTA2*M2)Mrc/Hoxb8^tm3.1(IRES-rtTA2*M2)Mrc Hoxc8^tm2.1(cre)Mrc/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:4818894

Genotype
MGI:4818894

cn1

• Allelic Composition: Hoxb8^{tm3.1(IRES-rtTA2*M2)Mrc}/Hoxb8^{tm3.1(IRES-rtTA2*M2)Mrc}; Hoxc8^{tm2.1(cre)Mrc}/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:162102 )

N • excessive grooming behavior is not observed in mutants

increased thermal nociceptive threshold ( J:162102 )

• mutants have significantly greater latency time in response to heat

nervous system

abnormal spinal cord dorsal horn morphology ( J:162102 )

• reduction in numbers interneurons in laminae I and II are detected, based on labeling for calbindin and calretinin

• in adult animals, significant decrease in neuronal cell body numbers is detected relative to wild-type controls