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Targeted Allele Detail
Symbol: Gys2tm1.1Pro
Name: glycogen synthase 2; targeted mutation 1.1, Peter J Roach
MGI ID: MGI:4462836
Synonyms: Gys2(Lox)
Gene: Gys2  Location: Chr6:142422613-142473109 bp, - strand  Genetic Position: Chr6, 74.04 cM
Decreased glycogen liver content in Gys2tm1.1Pro/Gys2tm1.1Pro Speer6-ps1Tg(Alb-cre)21Mgn/0 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:162043
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 5, and a floxed neo cassette was inserted downstream of exon 6. Cre mediated recombination removes the neo cassette leaving exons 5 and 6 floxed. (J:162043)
Generation of the floxed Gys2tm1.1Pro allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gys2 Mutation:  17 strains or lines available
Original:  J:162043 Irimia JM, et al., Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice. J Biol Chem. 2010 Apr 23;285(17):12851-61
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory